Subclinical Tick-Borne Encephalitis Virus in Experimentally Infected Apodemus agrarius

Autor:	László Egyed, Viktor Zöldi, Levente Szeredi
Rok vydání:	2015
Předmět:	Apodemus agrarius biology viruses Viral encephalitis virus diseases biology.organism_classification medicine.disease Virology Asymptomatic Virus Tick-borne encephalitis virus Infectious Diseases Immunology Apodemus medicine medicine.symptom Encephalitis Subclinical infection
Zdroj:	Intervirology. 58:369-372
ISSN:	1423-0100 0300-5526
DOI:	10.1159/000443833
Popis:	Objectives: In this study, we investigated the dose dependence of tick-borne encephalitis virus (TBEV) infection in one of the reservoirs, i.e. Apodemus agrarius, a small rodent species. Methods: The animals were challenged with TBEV per os and intramuscularly with infectious doses ranging from 1 to 1,500 plaque-forming units (pfu). Clinical signs were recorded and clinical and pathological features were evaluated by histological, immunohistochemical, and serological methods. Results: High perorally administered infectious doses resulted in virus replication in the brain, which is the first sign of subclinical viral encephalitis in the Apodemus genus. The animals seroconverted at infectious doses greater than 100 pfu, and all animals remained asymptomatic. Conclusion: Our work shows the first evidence that subclinical TBEV encephalitis may occur in Apodemus species, depending on the virus load of the inoculum. The antiviral response of the local innate immune system may influence the resistance of Apodemus individuals to lower infectious doses. Per oral/nasal infection seems to be more dangerous for the host than other routes of infection.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::04bcaef4b98262534faa88dda9fc2f97 https://doi.org/10.1159/000443833 Zobrazit plný text záznamu