Remembered saccades with variable delay in Parkinson's disease
| Autor: | Trevor J. Crawford, Erin O’Sullivan, Staira Blunt, Christopher Kennard, S. Shaunak, Leslie Henderson, Mark Lawden |
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| Rok vydání: | 1999 |
| Předmět: |
medicine.medical_specialty
Parkinson's disease genetic structures Working memory Audiology medicine.disease Spatial memory Central nervous system disease Dorsolateral prefrontal cortex medicine.anatomical_structure Neurology Basal ganglia Saccade medicine Neurology (clinical) Prefrontal cortex Psychology Neuroscience |
| Zdroj: | Movement Disorders. 14:80-86 |
| ISSN: | 1531-8257 0885-3185 |
| DOI: | 10.1002/1531-8257(199901)14:1<80::aid-mds1014>3.0.co;2-m |
| Popis: | The effect of increasing delay on the metrics of remembered saccades was studied in 10 subjects with mild Parkinson's disease, none of whom was receiving treatment with L-dopa, and nine age-matched control subjects. Delays of 1 msec, 250 msec, 1000 msec, 2500 msec, and 5000 msec were used, and reflexive saccades used as a control condition. Results were analyzed for the gain of the primary saccade and the accuracy of the final eye position (FEP gain). Reflexive saccades were normal in subjects with Parkinson's disease, but remembered saccades showed marked hypometria of primary saccade gain at all delays. FEP gain was unimpaired in Parkinson's disease, and primary saccade gain and FEP gain did not vary as a function of delay. Hypometria of primary saccades is compatible with dysfunction in striato-collicular inhibitory pathways in Parkinson's disease, arising as a functional consequence of dopamine deficiency in the basal ganglia. Maintenance of an accurate FEP gain suggests no deficit in oculomotor spatial working memory in Parkinson's disease, at least at delays of up to 5 sec. |
| Databáze: | OpenAIRE |
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