Enhancing the therapeutic effects of polyphenols with macromolecules
| Autor: | Cyrille Boyer, Susan Oliver, Giuseppe Cirillo, Orazio Vittorio |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Antioxidant
Polymers and Plastics Membrane permeability Chemistry medicine.medical_treatment Organic Chemistry food and beverages Bioengineering 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology Antimicrobial 01 natural sciences Biochemistry Neuroprotection 0104 chemical sciences Bioavailability In vivo Polyphenol medicine 0210 nano-technology Macromolecule |
| Zdroj: | Polymer Chemistry. 7:1529-1544 |
| ISSN: | 1759-9962 1759-9954 |
| Popis: | Well-known for their antioxidant properties, polyphenols are naturally occurring compounds containing one or more phenol groups. A high dietary intake of polyphenols has been linked to a reduced incidence of a number of diseases, including cancer, cardiovascular diseases, diabetes, osteoporosis and neurodegenerative diseases. Furthermore, in vitro and in vivo studies show the potential for polyphenols as therapeutic agents with cardioprotective, antimicrobial, anticancer, neuroprotective, and antidiabetic effects demonstrated. Despite their impressive therapeutic effects, polyphenols suffer from a number of drawbacks, including instability when exposed to light, heat and basic conditions; poor bioavailability; rapid metabolism; and poor membrane permeability. These drawbacks limit the clinical applications of polyphenols. Polymers and other macromolecules are well-known for their ability to stabilise and improve the bioavailability of therapeutic agents. A number of macromolecular systems have been developed that stabilise polyphenols whilst enhancing their therapeutic effects, including direct polymerisation of polyphenol monomers via step-growth, free radical and enzyme catalysed reactions; and conjugation with macromolecules via enzyme grafting, free-radical grafting, esterification and amidation. In this review, we will detail the key techniques employed to stabilise polyphenols with macromolecules and provide examples of each technique. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|