CD80 (B7.1) and CD54 (intracellular adhesion molecule-1) induce target cell susceptibility to promiscuous cytotoxic T cell lysis

Autor:	M Nishio, J Spielman, R K Lee, D L Nelson, E R Podack
Rok vydání:	1996
Předmět:	Immunology Immunology and Allergy
Zdroj:	The Journal of Immunology. 157:4347-4353
ISSN:	1550-6606 0022-1767
Popis:	Overexpression of B7 and intracellular adhesion molecule-1 (ICAM-1) on syngeneic cells triggered MHC-unrestricted lysis by MHC-restricted CD8+ CTL without TCR/CD3 engagement. Both CD28/B7 and LFA-1/ICAM-1 interactions were required for MHC-nonrestricted cytotoxicity. Cytotoxicity was measured in 4-h and 16- to 18-h cytotoxicity assays. B7-ICAM-1 overexpression triggered perforin- and Fas ligand-mediated lysis, while TNF-alpha was not elicited in MHC-unrestricted cytotoxicity. These results suggest that target cells may elicit MHC-unrestricted lysis from CTL through up-regulation of membrane adherence and costimulatory receptors.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::046641df0a73ff7304a51dace65b62d2 https://doi.org/10.4049/jimmunol.157.10.4347 Zobrazit plný text záznamu