Radiation and actinomycin D mortality studies in C57BL/6 MICE.II. Combined treatment and gastrointestinal lethality

Autor: Joseph P. Concannon, C. S. Weil, Milton H. Dalbow, Sheila E. Hodgson, R. Martinelli, R. F. Hagemann, John C. Frich
Rok vydání: 1973
Předmět:
Zdroj: Cancer. 32:553-561
ISSN: 1097-0142
0008-543X
Popis: C57BL/6 mice were treated with actinomycin or radiation therapy and with a combination of the two agents. LD50 estimates based on radiation doses were calculated from 6-day (intestinal death) mortality data. A factorial analysis of the data was performed to determine the. main effects for actinomycin (A) or radiation exposure (R) as well as actinomycin-radiation (AR) interactions. The LD50 data indicated that the effects of the combined treatment were generally more lethal in causing intestinal death than the effects of either agent given independently. Significant main effects for A and R were generally observed with few AR interactions. The principal mechanism for intestinal death in animals treated with various combinations of actinomycin and radiation exposure appears to be additive cytotoxicity either at the level of crypt survival and/or prolongation of the time to the appearance of the compensatory proliferative response.
Databáze: OpenAIRE
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