104. Overcrowding stress decreases macrophage activity and increases Salmonella Enteritidis invasion in broiler chickens
| Autor: | M.L. Pinheiro, A. Ribeiro, A.J. Ferreira, V. Ferraz-de-Paula, A.V. Gomes, C S Astolfi-Ferreira, A.T. Akamine, E. Baskeville, W.M. Quinteiro-Filho, João Palermo-Neto |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Salmonella
animal structures Endocrine and Autonomic Systems Salmonella enteritidis Immunology Broiler Biology medicine.disease_cause medicine.disease Small intestine Enteritis Microbiology Behavioral Neuroscience chemistry.chemical_compound medicine.anatomical_structure chemistry Intestinal mucosa Corticosterone medicine Bursa of Fabricius |
| Zdroj: | Brain, Behavior, and Immunity. 40:e30-e31 |
| ISSN: | 0889-1591 |
| DOI: | 10.1016/j.bbi.2014.06.124 |
| Popis: | Overcrowding stress is a reality in the poultry industry. Chickens exposed to long-term stressful situations present a reduction of welfare and immunosuppression. We designed this experiment to analyze the effects of overcrowding stress (16 birds/m 2 ) on performance parameters, serum corticosterone levels, the relative weight of the bursa of Fabricius, plasma IgA and IgG levels, intestinal integrity, macrophage activity and experimental Salmonella Enteritidis invasion. The overcrowding stress decreased performance parameters, induced enteritis and decreased macrophage activity and the relative bursa weight in broiler chickens. When the chickens were similarly stressed and infected with Salmonella Enteritidis , there was an increase in feed conversion and a decrease in plasma IgG levels in the stressed and Salmonella-infected birds. Moderate enteritis was observed throughout the duodenum of chickens stressed and infected with Salmonella. Moreover, the overcrowding stress decreased the macrophage phagocytosis intensity and increased Salmonella Enteritidis counts in the livers of birds challenged with the pathogenic bacterium. Thus, we believe that overcrowding stress via the hypothalamic–pituitary–adrenal axis that is associated with an increase in corticosterone and enteritis might influence the quality of the intestinal immune barrier and the integrity of the small intestine. This effect allowed pathogenic bacteria to migrate through the intestinal mucosa, resulted in inflammatory infiltration and Salmonella invasion. |
| Databáze: | OpenAIRE |
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