A Patient with an Unusual Circulating Anticoagulant

Autor:	K. W. E. Denson, Rosemary Biggs, H. L Nossel
Rok vydání:	1964
Předmět:	Geriatrics medicine.medical_specialty chemistry.chemical_compound Factor VII chemistry Circulating anticoagulant business.industry Internal medicine medicine Hematology business Gastroenterology Blood coagulation test
Zdroj:	Thrombosis and Haemostasis. 12:001-011
ISSN:	2567-689X 0340-6245
DOI:	10.1055/s-0038-1655571
Popis:	SummaryThe investigation of a patient with an inhibitor which destroyed factor VIII is described. The inhibitor was active at high dilution but inactivated only 70–80 per cent of added factor VIII if tested by a two-stage assay method. Using a one-stage method 90–95 per cent of the activity disappeared. Thus, according to the method used, 5–30 per cent of factor VIII remained in the patient’s plasma. No other type of inhibitor was detected, yet the whole blood clotting time was prolonged and experience with haemophilic patients suggests that factor VIII levels between 5 and 30 per cent of normal should be accompanied by normal clotting time.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::04531b7ff7d7d103aae82daa89aab580 https://doi.org/10.1055/s-0038-1655571 Zobrazit plný text záznamu