Association of insulinase gene polymorphisms with type 2 diabetes mellitus in patients from the Moscow population

Autor:	O. V. Pivovarova, M. I. Shadrina, Svetlana A. Limborska, F. G. Pfaipffer, S. E. Agadghanyan, P. A. Slominsky, Natalia Rudovich, V. S. Pronin, A. V. Artem’eva
Rok vydání:	2009
Předmět:	Genetics education.field_of_study endocrine system diseases Population nutritional and metabolic diseases Type 2 Diabetes Mellitus Single-nucleotide polymorphism Biology Genotype frequency Genotype SNP Allele education TCF7L2
Zdroj:	Russian Journal of Genetics. 45:113-117
ISSN:	1608-3369 1022-7954
DOI:	10.1134/s1022795409010165
Popis:	Association of 13 single nucleotide polymorphisms (SNPs) of insulinase (IDE) gene with type 2 diabetes mellitus (T2D) in the Moscow population has been examined. Three polymorphic markers (rs7078413, rs7899603, and rs551266) associated with the risk of T2D development have been revealed. Allele and genotype frequency distribution for these three markers differed significantly only in the sample of females between T2D patients and control individuals, while only in case of rs7078413 SNP genotype frequencies varied significantly in the total population.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0452d5c5f9d7d6543695a26928a89d7f https://doi.org/10.1134/s1022795409010165 Zobrazit plný text záznamu Full text from SpringerLink