| Autor: |
Keiichiro Minatohara, Hiroyuki Okuno, Anna Araki |
| Rok vydání: |
2015 |
| Předmět: |
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| Zdroj: |
Novel Mechanisms of Memory ISBN: 9783319243627 |
| DOI: |
10.1007/978-3-319-24364-1_6 |
| Popis: |
Long-term synaptic plasticity and memory formation require activity-dependent gene expression. However, it remains unknown how such activity-induced gene products are targeted to proper cellular compartments including synapses. Investigation of the targeting of the memory related-protein Arc from the soma to the synapses have elucidated a novel “inverse” synaptic tagging mechanism that enables Arc to specifically target the un-potentiated synapses. The findings provide new mechanistic insights into how the contrast between strong and weak synapses is maintained during long-term synaptic plasticity. Furthermore, they facilitate a better understanding of the molecular basis of biochemical memory at individual synapses and ultimately learning and memory. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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