Partial Liquid Ventilation with Perflubron in Premature Infants with Severe Respiratory Distress Syndrome
| Autor: | T. H. Shaffer, Corinne L. Leach, R DeLemos, M. R. Wolfson, S. D. Rubenstein, Jay S. Greenspan, J C Jackson, Bradley P. Fuhrman |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Mechanical ventilation
Respiratory distress Perflubron business.industry medicine.medical_treatment Respiratory disease General Medicine Surfactant therapy medicine.disease chemistry.chemical_compound Functional residual capacity chemistry Anesthesia medicine Breathing Partial liquid ventilation business |
| Zdroj: | New England Journal of Medicine. 335:761-767 |
| ISSN: | 1533-4406 0028-4793 |
| DOI: | 10.1056/nejm199609123351101 |
| Popis: | Background The intratracheal administration of a perfluorocarbon liquid during continuous positive-pressure ventilation (partial liquid ventilation) improves lung function in animals with surfactant deficiency. Whether partial liquid ventilation is effective in the treatment of infants with severe respiratory distress syndrome is not known. Methods We studied the efficacy of partial liquid ventilation with perflubron in 13 premature infants with severe respiratory distress syndrome in whom conventional treatment, including surfactant therapy, had failed. Partial liquid ventilation was initiated by instilling perflubron during conventional mechanical ventilation to a volume approximating the functional residual capacity. Infants were considered to have completed the study if they received partial liquid ventilation for at least 24 hours. Results Ten infants received partial liquid ventilation for 24 to 76 hours. In the other three infants, partial liquid ventilation was discontinued within four hours in fa... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|