Expression of Genes and Proteins of the Sarcoplasmic Reticulum Са2+-Transport Systems in Cardiomyocytes in Concomitant Coronary Heart Disease and Type 2 Diabetes Mellitus
| Autor: | Boris N Kozlov, Sh D Akhmedov, S A Afanas'ev, D S Kondrat'eva, О. V. Budnikova, E F Muslimova |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
business.industry Ryanodine receptor Endoplasmic reticulum Type 2 Diabetes Mellitus General Medicine Calsequestrin Ryanodine receptor 2 General Biochemistry Genetics and Molecular Biology Endocrinology Internal medicine Concomitant ATP2A2 cardiovascular system medicine business Gene |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 172:117-120 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-021-05346-6 |
| Popis: | We compared the expression of Са2+-ATPase (SERCA2a), calsequestrin (CASQ2), ryanodine receptors (RyR2) proteins and their genes (ATP2A2, CASQ2, and RYR2) in coronary heart disease (CHD) patients with and without comorbid type 2 diabetes mellitus. All studies were performed on the right atrial appendages resected during coronary bypass surgeries. Expression of SERCA2a and RyR2 proteins and their ATP2A2 (p=0.046) and RYR2 genes in comorbid pathology was significantly (p=0.042) higher (by 1.2 and 2 times; p=0.025). The expression of CASQ2 protein and its gene did not differ significantly between the groups (p=0.82 and p=0.066, respectively). It was concluded that the expression of SERCA2a and RyR2 proteins and their genes (but not CASQ2 and its gene) is elevated in CHD associated with type 2 diabetes mellitus. Expression of the studied proteins correlated with the expression of their genes. Increased expression of CASQ2 protein and its gene can probably prevent imbalance of the Ca2+-transporting systems in cardiomyocytes and contractile dysfunction of the myocardium, even in CHD associated with type 2 diabetes mellitus. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink