Inhibitory Effects of Brazilian Propolis on Tumor Promotion in Two-Stage Mouse Skin Carcinogenesis
| Autor: | null Ken Yasukawa, null So Yeon Yu, null Shigetoshi Tsutsumi, null Masahiko Kurokawa, null Yong K. Park |
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| Rok vydání: | 2012 |
| Předmět: |
Nutrition and Dietetics
Health (social science) integumentary system Medicine (miscellaneous) Propolis Biology medicine.disease_cause Inhibitory postsynaptic potential Mouse skin medicine Cancer research Tumor promotion General Pharmacology Toxicology and Pharmaceutics Stage (cooking) Carcinogenesis |
| Zdroj: | Journal of Pharmacy and Nutrition Sciences. 2:71-76 |
| ISSN: | 1927-5951 2223-3806 |
| DOI: | 10.6000/1927-5951.2012.02.01.10 |
| Popis: | Propolis is produced by honeybees and has many biological properties, including immunomodulatory, anti-inflammatory, anti-oxidant, anti-bacterial, anti-viral and anti-cancer actions. Five ethanol extracts of Brazilian propolis were tested for inhibition of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice. The ethanol extract of Brazilian propolis AF-08 markedly inhibited TPA-induced inflammatory ear edema in mice. This extract suppressed tumor promotion by TPA following initiation with 7,12-dimethylbenz[a]anthracene (DMBA) in mouse skin. Moronic acid, a major component of Brazilian propolis AF-08, markedly inhibited two-stage carcinogenesis by DMBA plus TPA. These results suggest that Brazilian propolis AF-08 contributes to the prevention of cancer. |
| Databáze: | OpenAIRE |
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