Synthesis of novel zerumbone derivatives via regioselective palladium catalyzed decarboxylative coupling reaction: a new class of α-glucosidase inhibitors

Autor:	B. P. Dhanya, Nayana Joseph, Kokkuvayil Vasu Radhakrishnan, K.R. Ajish, V. P. Vineetha, M. Priya Rani, Kozhiparambil Gopalan Raghu
Rok vydání:	2014
Předmět:	chemistry.chemical_classification Double bond Chemistry α glucosidase Organic Chemistry Regioselectivity chemistry.chemical_element Biochemistry Combinatorial chemistry Coupling reaction Catalysis In vitro analysis Enzyme Drug Discovery Palladium
Zdroj:	Tetrahedron Letters. 55:665-670
ISSN:	0040-4039
Popis:	A new strategy for the synthesis of novel zerumbone derivatives via a regioselective palladium catalyzed decarboxylative coupling reaction using arene carboxylic acids is described. The current methodology involves the repositioning of endocyclic double bond to exocyclic double bond of zerumbone. Preliminary in vitro analysis revealed that most of the newly synthesized derivatives are potent α-glucosidase enzyme inhibitors.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::041259f935bf321793df2179215f1ba5 https://doi.org/10.1016/j.tetlet.2013.11.110 Zobrazit plný text záznamu Full Text from ScienceDirect