Apparent different thrombotic tendency in patients with factor V Leiden and protein C deficiency due to selection of patients
| Autor: | F.R. Rosendaal, Pieter H. Reitsma, Ted Koster, C.F. Allaart, Rogier M. Bertina, Jan P. Vandenbroucke, Ruud Lensen, H de Ronde |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
medicine.medical_specialty
education.field_of_study business.industry Immunology Population Cell Biology Hematology medicine.disease Thrombophilia Biochemistry Gastroenterology Thrombosis Surgery Venous thrombosis Protein C deficiency Internal medicine medicine Factor V Leiden Age of onset education business Protein C medicine.drug |
| Zdroj: | Blood. 88:4205-4208 |
| ISSN: | 1528-0020 0006-4971 |
| DOI: | 10.1182/blood.v88.11.4205.4205 |
| Popis: | Both activated protein C (APC) resistance and protein C deficiency are associated with an increased risk for venous thrombosis. To assess their tendencies to venous thrombosis, we compared the median age of first venous thromboembolism in patients with factor V Leiden or protein C deficiency, who were identified either within unselected consecutive cases with a first deep venous thrombosis derived from a population-based case-control study, or identified by selection of patients with a deep venous thrombosis, who were referred for thrombophilIa work-up. The median age of onset for 92 unselected APC resistant cases was 43 years and for 13 unselected protein C-deficient cases 47 years. The median age at the first thrombotic event for 28 APC- resistant members of thrombophilia families was 29 years and for 50 protein C-deficient members of thrombophilia families 31.5 years. The median age of onset for all unselected patients (n=105) was 45 years of age (range, 16 to 69 years) and the median age of onset for all selected patients from the thrombophilia families (n=78) was 30.5 years (range, 16 to 67 years). These results show that within the case-control study and the family studies, the median age of onset is very similar in patients with APC resistance and patients with protein C deficiency. This suggests that APC resistance is not less severe with respect to risk of thrombosis than (heterozygous) protein C deficiency. In conclusion, the median age at which the first thrombosis occurs mainly depends on the way the patients are identified and not on the type of thrombophilia. |
| Databáze: | OpenAIRE |
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