Prognostic Value of TWIST1 and EZH2 Expression in Colon Cancer
| Autor: | Taiseer R. Ibrahim, Mohamed I Farid, Samar M Abdel Raouf, Salem Y Mohamed, Lobna A. Abdelaziz |
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| Rok vydání: | 2019 |
| Předmět: |
animal structures
Colon Adenoma Colorectal cancer business.industry medicine.medical_treatment EZH2 Gastroenterology macromolecular substances medicine.disease medicine.disease_cause digestive system diseases Radiation therapy 03 medical and health sciences 0302 clinical medicine Oncology 030220 oncology & carcinogenesis medicine Cancer research Carcinoma Immunohistochemistry 030211 gastroenterology & hepatology business Carcinogenesis Transcription factor |
| Zdroj: | Journal of Gastrointestinal Cancer. 52:90-98 |
| ISSN: | 1941-6636 1941-6628 |
| Popis: | Colorectal carcinoma (CRC) is the third most common human cancer. Twist, a basic helix-loop-helix (bHLH) transcription factor, is an epithelial-mesenchymal transition ((EMT) inducer that has been involved in carcinogenesis and chemoresistance. Also, the enhancer of Zeste homolologue2 (EZH2), a member of the polycomb group of genes, had been associated with poor prognosis in several malignancies. To evaluate the expression of Twist1 and EZH2 in colon carcinoma in Egyptian patients and its relation to clinicopathological parameters, prognosis, and survival. Twist1 and EZH2 expressions were evaluated immunohistochemically in 50 cases of colorectal tumors (12 colon adenomas and 38 colon carcinomas) and 20 samples from normal colonic mucosa. The expression of Twist1 and EZH2 was significantly higher in colon adenoma and carcinoma than that in normal colonic mucosa (P < 0.05). Twist1 and EZH2 expressions were associated with decreased tumor differentiation, advanced stage, and lymph node metastasis. Twist1 and EZH2 expressions were significantly related to 3-year disease-free survival (P = 0.005 and 0.002 respectively) and 3-year overall survival (P = 0.045 and 0.039, respectively). Twist1 and EZH2 may serve as prognostic predictors for colon carcinoma and may have a potential role as therapeutic targets in patients with colon carcinoma in the future. |
| Databáze: | OpenAIRE |
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