ChemInform Abstract: Dual-Action Cephalosporins: Cephalosporin 3′-Quinolone Carbamates
| Autor: | Harry Allen Albrecht, Dennis D. Keith, J. G. Christenson, Chung-Chen Wei, Konzelmann Frederick Martin, N H Georgopapadakou, G. Beskid, Rossman Pamela Loreen, David L. Pruess |
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| Rok vydání: | 2010 |
| Předmět: |
Carbamate
medicine.drug_class Chemistry Stereochemistry medicine.medical_treatment Cephalosporin Antibiotics General Medicine biochemical phenomena metabolism and nutrition Quinolone Ciprofloxacin chemistry.chemical_compound Mechanism of action medicine medicine.symptom Mode of action Bifunctional medicine.drug |
| Zdroj: | ChemInform. 23 |
| ISSN: | 0931-7597 |
| DOI: | 10.1002/chin.199210294 |
| Popis: | A series of cephalosporins has been prepared in which the 3'-position was linked to the nitrogen of the antibacterial quinolone ciprofloxacin through a carbamate function. Like the ester-linked and quaternary-linked dual-action cephalosporins reported earlier, these carbamate-linked compounds exhibited a broad antibacterial spectrum derived from both cephalosporin-like and quinolone-like activities, suggesting a dual mode of action. Studies to elucidate details of the mechanism of action have been inconclusive. Ciprofloxacin liberated as a consequence of bacterial enzyme-mediated reactions may contribute to the second mode of action, although some evidence indicates that the intact carbamate-linked bifunctional molecules may possess intrinsically both beta-lactam and quinolone activities. |
| Databáze: | OpenAIRE |
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