Occurrence Rates of Gram-negative Bacteria after Treatment with Anti Methicillin-resistant Staphylococcm Aureus Agents

Autor:	Fumiyoshi Ojima, Teiko Toyoguchi, Mitsutaka Ebihara, Yoshito Nakagawa, Jun Hosoya
Rok vydání:	2004
Předmět:	Gram-negative bacteria biology medicine.drug_class Antibiotics biology.organism_classification medicine.disease_cause Microbiology Staphylococcus aureus medicine Vancomycin Arbekacin In patient After treatment Bacteria medicine.drug
Zdroj:	Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences). 30:651-655
ISSN:	1882-1499 1346-342X
DOI:	10.5649/jjphcs.30.651
Popis:	Methicillin-resistant Staphylococcus aureus (MRSA) is a gram-positive bacterium, and the treatment of patients with MRSA has induced microbial substitution. Regarding antibiotics used for treatment, vancomycin (VCM) has an antibacterial action only against gram-positive bacteria, while arbekacin (ABK) has an antibacterial action against both gram-positive and gram-negative bacteria. In view of this, we supposed that there would be a difference in gram-negative bacteria occurrence rates between patients administered VCM and those administered ABK and tested this supposition by comparing the appearance of gram-negative bacteria in these two patient groups. While gram-negative bacteria were newly detected in 45% of patients after receiving VCM, no patients receiving ABK showed any new gram-negative bacteria. On the other hand, gram-negative bacteria were still detected after administering ABK in patients who had gram-negative bacteria beforehand. This finding suggests that ABK may not be a superior agent when gram-negative bacteria are already present.
Databáze:	OpenAIRE
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