Methyl esters: an alternative protecting group for the synthesis of O-glycosyl amino acid building blocks

Autor:	Rosa L. Dorta, Carlos Mayato, Jesús T. Vázquez
Rok vydání:	2008
Předmět:	chemistry.chemical_classification Stereochemistry Carboxylic acid Organic Chemistry Biochemistry Glycopeptide Amino acid carbohydrates (lipids) chemistry.chemical_compound chemistry Drug Discovery Organic chemistry lipids (amino acids peptides and proteins) Glycosyl Protecting group
Zdroj:	Tetrahedron Letters. 49:1396-1398
ISSN:	0040-4039
Popis:	The glycosyl amino acids α-GalNAc-Ser and α-GalNAc-Thr are fundamental building blocks for glycopeptide synthesis, Schmidt’s synthesis method often being chosen for this purpose. Methyl esters used as orthogonal carboxylic acid protecting group in this procedure were found to be an efficient and inexpensive alternative to other groups. The mild selective methyl ester deprotection by LiI improved the efficiency of the synthesis method.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::03fdb32da6a842c36ac39e32d4fb8865 https://doi.org/10.1016/j.tetlet.2007.12.078 Zobrazit plný text záznamu Full Text from ScienceDirect