pH-Responsive Transferrin-pHlexi Particles Capable of Targeting Cells in Vitro
| Autor: | Shenglin Yang, Georgina K. Such, Laura I. Selby, Adelene S. M. Wong, Rebecca Y. Hodgetts, Angus P. R. Johnston, Kristofer I. Cupic, Moore Z. Chen, Daniel Yuen, Ewa Czuba |
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| Rok vydání: | 2017 |
| Předmět: |
chemistry.chemical_classification
Materials science Polymers and Plastics Organic Chemistry Radical polymerization Nanoparticle macromolecular substances 02 engineering and technology Polymer Conjugated system 010402 general chemistry 021001 nanoscience & nanotechnology Methacrylate 01 natural sciences 3. Good health 0104 chemical sciences Inorganic Chemistry chemistry.chemical_compound chemistry PEG ratio Polymer chemistry Materials Chemistry Copolymer 0210 nano-technology Ethylene glycol |
| Zdroj: | ACS Macro Letters. 6:315-320 |
| ISSN: | 2161-1653 |
| DOI: | 10.1021/acsmacrolett.7b00044 |
| Popis: | Targeting nanoparticles to specific cellular receptors has the potential to deliver therapeutic compounds to target sites while minimizing side effects. To this end, we have conjugated a targeting protein, holo-transferrin (holo-Tf), to pH-responsive polymers, poly(2-(diethylamino)ethyl methacrylate) (PDEAEMA) and poly(2-(diethylamino)ethyl methacrylate)-ran-poly(2-(diisopropylamino)ethyl methacrylate (PDEAEMA-r-PDPAEMA). These protein–polymer hybrid materials were observed to self-assemble when the pH is increased above the pKa of the polymer. We demonstrate that their response to pH could be tuned depending on the polymer constituent attached to holo-Tf. Importantly, the targeting behavior of these nanoparticles could be maximized by tuning the density of holo-Tf on the nanoparticle surface by the introduction of a (PDEAEMA-r-PDPAEMA)-b-poly(ethylene glycol) (PEG) copolymer. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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