Perinatal Inflammation Reprograms Neuroendocrine, Immune, and Reproductive Functions: Profile of Cytokine Biomarkers
| Autor: | Marina Izvolskaia, Viktoriya S. Sharova, L. A. Zakharova |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Infertility business.industry Offspring medicine.medical_treatment Immunology Interleukin Inflammation Systemic inflammation medicine.disease 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Cytokine Immune system 030220 oncology & carcinogenesis medicine Immunology and Allergy Tumor necrosis factor alpha medicine.symptom business |
| Zdroj: | Inflammation. 43:1175-1183 |
| ISSN: | 1573-2576 0360-3997 |
| Popis: | Viral and bacterial infections causing systemic inflammation are significant risk factors for developing body. Inflammatory processes can alter physiological levels of regulatory factors and interfere with developmental mechanisms. The brain is the main target for the negative impact of inflammatory products during critical ontogenetic periods. Subsequently, the risks of various neuropsychiatric diseases such as Alzheimer's and Parkinson's diseases, schizophrenia, and depression are increased in the offspring. Inflammation-induced physiological disturbances can cause immune and behavioral disorders, reproductive deficiencies, and infertility. The influence of maternal immune stress is mediated by the regulation of pro-inflammatory cytokines such as interleukin (IL)-1β, IL-6, monocyte chemotactic protein 1, leukemia-inhibiting factor, and tumor necrosis factor-alpha secretion in the maternal-fetal system. The increasing number of patients with neuronal and reproductive disorders substantiates the identification of biomarkers for these disorders targeted at their therapy. |
| Databáze: | OpenAIRE |
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