MHC II α polymorphism of Nile tilapia, Oreochromis niloticus, and its association with the susceptibility to Gyrodactylus cichlidarum (Monogenea) infection
| Autor: | Yingying Zheng, Tingting Zhi, Shuai Zhang, Tingbao Yang, Christopher L. Brown, Xiangli Xu, Jinsong Chen |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Genetics
0303 health sciences biology 04 agricultural and veterinary sciences Aquatic Science biology.organism_classification Major histocompatibility complex 03 medical and health sciences Oreochromis Nile tilapia Polymorphism (computer science) 040102 fisheries biology.protein 0401 agriculture forestry and fisheries Gene polymorphism Allele Gene Monogenea 030304 developmental biology |
| Zdroj: | Aquaculture. 539:736637 |
| ISSN: | 0044-8486 |
| DOI: | 10.1016/j.aquaculture.2021.736637 |
| Popis: | Nile tilapia, Oreochromis niloticus, is among the most preeminent aquaculture species in the world. In aquaculture systems, this species is vulnerable to various pathogens including Gyrodactylus cichlidarum (Monogenea). The major histocompatibility complex (MHC) genes, a highly polymorphic gene superfamily, have vital roles in adaptive immunity and are closely associated with disease resistance. In the present study, the relationship between MHC II α polymorphism of Oreochromis niloticus and the susceptibility to G. cichlidarum infection were analyzed. A total of 50 alleles of MHC II α were identified, which demonstrated a high level of polymorphism representing a variability of 89.6% amino acid sites. In the peptide-binding region (PBR) and entire region, the values of dN to dS were 1.155 and 1.180, respectively. Infection experiments revealed that hosts with moderate polymorphism of MHC II α (2 to 3 alleles) had relatively higher resistance to G. cichlidarum infection. In addition, the alleles Orni-DAA*0201 and Orni-DAA*0701 were found to be significantly associated with susceptibility (P |
| Databáze: | OpenAIRE |
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