Research Experience for the Organic Chemistry Laboratory: A Student-Centered Optimization of a Microwave-Enhanced Williamson Ether Synthesis and GC Analysis
| Autor: | Marsha R. Baar |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
010405 organic chemistry
Chemistry education 05 social sciences Student centered 050301 education General Chemistry 01 natural sciences 0104 chemical sciences Education Potassium carbonate Williamson ether synthesis chemistry.chemical_compound Bromide Reagent Organic chemistry SN2 reaction Acetonitrile 0503 education Microwave |
| Zdroj: | Journal of Chemical Education. 95:1235-1237 |
| ISSN: | 1938-1328 0021-9584 |
| DOI: | 10.1021/acs.jchemed.7b00592 |
| Popis: | An inquiry-based experiment for the organic chemistry laboratory was developed to provide students with a cognitively rich research experience. Student teams were charged with optimizing the reaction conditions for the Williamson ether synthesis of 2-fluorophenetole from 2-fluorophenol, ethyl bromide, and potassium carbonate in either absolute ethanol or acetonitrile. Microwave acceleration of this SN2 reaction followed by rapid GC–MS analysis allowed students to review results, revise experimental conditions, and repeat the modified reaction and its analysis within a 3 h laboratory period. Variables that could be manipulated were reagent equivalencies, solvents and their volume, microwave reaction time, temperature, and wattage. Post-laboratory, all team data were available to the entire class for additional evaluation and each student was required to suggest new conditions for improvement in his/her laboratory report. |
| Databáze: | OpenAIRE |
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