Bioaccessibility of bioactive peptides: recent advances and perspectives
| Autor: | Joy I. Obeme-Nmom, Innocent Uzochukwu Okagu, Chibuike C. Udenigwe, Raliat O. Abioye |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Proteases 030109 nutrition & dietetics 04 agricultural and veterinary sciences Computational biology Biology Health benefits 040401 food science Applied Microbiology and Biotechnology 03 medical and health sciences 0404 agricultural biotechnology Oral ingestion Nutraceutical Food Science |
| Zdroj: | Current Opinion in Food Science. 39:182-189 |
| ISSN: | 2214-7993 |
| Popis: | Food-derived bioactive peptides are gaining popularity for their vast amount of potential health benefits against diseases such as obesity, hypertension, type 2 diabetes, and many more. However, many of these bioactivities are demonstrated using in vitro models, which do not completely reflect the true conditions that peptides experience upon oral ingestion. Furthermore, results obtained from in vivo studies are not entirely reproducible in other in vivo models due to systemic physiological differences. This review discusses the different bioaccessibility challenges, such as gastrointestinal tract hydrolysis by proteases, food matrix interactions, and intestinal barrier interaction that must be considered when developing peptide-based nutraceuticals or functional foods. The paper also discusses the potential avenues for improving bioaccessibility of bioactive peptides, amongst other factors that should be considered, during the design and production phases. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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