Genetic testing and counselling for hereditary colorectal cancer

Autor:	J. D. Trimbath, F. M. Giardiello
Rok vydání:	2002
Předmět:	Oncology medicine.medical_specialty Hepatology medicine.diagnostic_test business.industry Colorectal cancer Genetic counseling Gastroenterology Rectum Gene mutation medicine.disease Genetic determinism Review article medicine.anatomical_structure Internal medicine Medicine Pharmacology (medical) business Lung cancer Genetic testing
Zdroj:	Alimentary Pharmacology & Therapeutics. 16:1843-1857
ISSN:	0269-2813
DOI:	10.1046/j.1365-2036.2002.01357.x
Popis:	Summary Colorectal cancer is the second leading cause of cancer death, after lung cancer, in the USA. The great majority (80%) of patients with colorectal cancer have sporadic disease with no evidence of having inherited the disorder. In the remaining 20%, a potentially definable genetic component exists. With the discovery of gene mutations related to hereditary colorectal cancer, risk assessment based on genetic test results is now feasible. The following review focuses on the two well-described colorectal cancer genetic syndromes—familial adenomatous polyposis and hereditary nonpolyposis colorectal cancer, the process of genetic counselling, currently available genetic tests, and indications for their use.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::03d393aa2e6a2211a12c4bdb3a70280f https://doi.org/10.1046/j.1365-2036.2002.01357.x Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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