Total synthesis of biologically active alkaloids using transition metals

Autor:	Sabine Richter, Roman Fedorov, Markus Böhl, Hans-Joachim Knölker, Kerstin E. Knott, Konstanze K. Gruner, René Martin, Ronny Forke, Herwig O. Gutzeit, Georgios Tsiavaliaris, Sameer Agarwal, Dietmar J. Manstein, Stefan Auschill
Rok vydání:	2010
Předmět:	Myosin ATPase Chemistry Carbazole Stereochemistry General Chemical Engineering Allosteric regulation Total synthesis chemistry.chemical_element Biological activity General Chemistry Ring (chemistry) chemistry.chemical_compound Transition metal heterocyclic compounds Palladium
Zdroj:	Pure and Applied Chemistry. 82:1975-1991
ISSN:	1365-3075 0033-4545
DOI:	10.1351/pac-con-09-12-15
Popis:	We have developed efficient synthetic routes to heterocyclic ring systems using transition metals (palladium, iron, and silver). Recent applications of this chemistry to the total synthesis of biologically active alkaloids include carbazole alkaloids (pityriazole, euchrestifoline, the antiostatins), crispine A, pentabromo- and pentachloropseudilin. The two latter alkaloids represent a novel class of myosin ATPase inhibitors that led to the discovery of a new allosteric binding site of the protein.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::03d000c3591de3b0263a32da3ddf40fe https://doi.org/10.1351/pac-con-09-12-15 Zobrazit plný text záznamu Plný text ve formátu PDF