Effects of Hydroxyapatite/Silk Fibroin/Chitosan Ratio on Physical Properties of Scaffold for Tissue Engineering Application
| Autor: | Wassanai Wattanutchariya, Kittiya Thunsiri, Atitaya Oonjai |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
010302 applied physics
Scaffold Morphology (linguistics) Materials science Mechanical Engineering Fibroin 02 engineering and technology Adhesion Biodegradation 021001 nanoscience & nanotechnology Condensed Matter Physics 01 natural sciences Chitosan chemistry.chemical_compound chemistry Tissue engineering Mechanics of Materials 0103 physical sciences Degradation (geology) General Materials Science Composite material 0210 nano-technology |
| Zdroj: | Materials Science Forum. 872:261-265 |
| ISSN: | 1662-9752 |
| DOI: | 10.4028/www.scientific.net/msf.872.261 |
| Popis: | This study reports the effects of the mixing ratio of hydroxyapatite (HA), silk fibroin (SF) and chitosan (CS) on the physical properties of the scaffold used in tissue engineering. Experimental design based on mixture design was implemented to investigate the degradation rate of the scaffolds fabricated from various ratios of those biomaterials. Furthermore, pore morphology and pore size were evaluated to confirm the compatibility of the scaffold topography for cell growth and adhesion. The results from the study showed that all ratios, except pure HA solution, can be fabricated into porous scaffolds with an interconnected pore structure and appropriate pore sizes to allow all types of human cells to pass through. Furthermore, the scaffold solutions with high CS ratio resulted in a uniform pore structure and lower rates of biodegradation. Therefore, CS is recommended as the main structure because it provides the highest resistance to biodegradation. The scaffolds from various ratios may be applied for different tissue replacements in the near future. |
| Databáze: | OpenAIRE |
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