Association of HLA-DRB1*15 allele and CSF oligoclonal bands in a Spanish multiple sclerosis cohort

Autor:	J. María Pujal, J. Bas, Elisabet Matas, Sergio Martínez-Yélamos, L Romero-Pinel, L. Gubieras, F. Morandeira, T. Arbizu, Laura Bau
Rok vydání:	2011
Předmět:	education.field_of_study business.industry Multiple sclerosis Population Human leukocyte antigen medicine.disease Cerebrospinal fluid Neurology Genotype Immunology medicine Neurology (clinical) Typing Allele education business HLA-DRB1
Zdroj:	European Journal of Neurology. 18:1258-1262
ISSN:	1351-5101
DOI:	10.1111/j.1468-1331.2011.03379.x
Popis:	Background and objective: The HLA-DRB1*15 allele is consistently associated with multiple sclerosis (MS) susceptibility in most studied populations. This study investigated the association between HLA-DRB1 alleles and the presence of oligoclonal immunoglobulin G bands (OCB) in the cerebrospinal fluid (CSF) in a Spanish population with MS. Methods: The HLA-DRB1 typing was performed in 268 patients with sporadic MS and the detection of OCB in CSF. HLA-DRB1 allelic frequencies were compared between OCB-positive and OCB-negative patients, and both groups were also compared with 1088 unrelated healthy controls. Moreover, we correlated the various HLA-DRB1 genotypes, considering all the combinations of both parental alleles found with the presence or absence of OCB. Results: We found 206 OCB-positive and 62 OCB-negative patients. The HLA-DRB1*15 allele in OCB-positive patients had a higher frequency when compared with OCB-negative patients (39.3% in OCB-positive vs. 16.1% in OCB-negative, OR = 1.38 95% CI = 1.18–1.61, P
Databáze:	OpenAIRE
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