Comparison of panendoscopy directed biopsies with percutaneous and image-guided biopsies during immune checkpoint inhibitor therapy

Autor: Ariel Ann Nelson, David Pfau, Ahmad F Hashmi, Christopher J. Hoimes, Nikhil H. Ramaiya, Daniel A. Smith, Amir Ata Rahnemai-Azar, Pavitra Ravishankar
Rok vydání: 2019
Předmět:
Zdroj: Journal of Clinical Oncology. 37:e14084-e14084
ISSN: 1527-7755
0732-183X
DOI: 10.1200/jco.2019.37.15_suppl.e14084
Popis: e14084 Background: Immune checkpoint inhibitors (ICI) have been shown to be helpful in the treatment of a several cancers. Response to ICI therapy is varied. The goal of this study was to examine the role of pan-endoscopy guided biopsies as well as image-guided and percutaneous biopsies as a means to tailor treatment regimens for patients receiving ICI therapy. Methods: A retrospective chart review was performed on oncology patients at a single institution from 2010 from 2018 undergoing treatment with ICI (n = 1044). Patients undergoing biopsies within the treatment period and up to one month following conclusion of treatment were analyzed and separated into a pan-endoscopy guided biopsy cohort or image-guided/percutaneous biopsy cohort. Data regarding biopsy results and subsequent treatment plans was then gathered and compared. Results: 5.3% of patients underwent pan-endoscopy guided biopsy (n = 55). 6.0% of patients underwent image-guided/percutaneous biopsy (n = 63). The most common endoscopic procedures included EGD 42.6%, bronchoscopy 38.9%, and flexible sigmoidoscopy/colonoscopy 20.4%. The most common image/percutaneously sampled tissues included skin/soft tissue 24.6%, lymph nodes 19.7%, and liver 16.4%. Breakdown of treatment complications in the pan-endoscopy group included pneumonitis 3.2%, inflammatory or infectious esophagitis 6.4%, or colitis 4.3%. Treatment complications in the image guided/percutaneous group included skin reactions 2.2% and inflammatory mediastinal changes 1.1%. Conclusions: In our cohort, Pan endoscopy and image guided/percutaneous biopsies were successfully performed along multiple cancer cell lines and helped in the decision making process.[Table: see text]
Databáze: OpenAIRE
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