Gene Knockout Mice in the Study of Parturitions

Autor:	Louis J. Muglia, Takuji Imamura, Gil Gross
Rok vydání:	2000
Předmět:	chemistry.chemical_classification medicine.medical_specialty Obstetrics and Gynecology Neuropeptide Prostaglandin Gene mutation Biology chemistry.chemical_compound Enzyme Endocrinology chemistry Oxytocin Internal medicine medicine Receptor Gene knockout medicine.drug Hormone
Zdroj:	Journal of the Society for Gynecologic Investigation. 7:88-95
ISSN:	1071-5576
DOI:	10.1177/107155760000700202
Popis:	To review recent studies of parturition control in mice with relevance to understanding the control of human parturition Assimilation of published studies of gene knockout mice with mutations in neuropeptides, prostaglandin synthetic enzymes and receptors, and other molecules implicated in parturition. The central role of prostaglandins in murine labor is demonstrated by mice with gene mutations at multiple levels of the prostaglandin synthetic pathway. In addition, novel molecules such as steroid 5α-reductase are found to play an essential role in the progression of labor. Surprisingly, deficiency of neuropeptides such as oxytocin and corticotropin-releasing hormone have little effect on parturition. Molecular genetic analyses in mice provide an efficient way to define molecules critical for murine parturition. Extrapolation of the importance of these molecules to human parturition provides the next challenge.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::03ac31a72671e521cfbea7d3a899e054 https://doi.org/10.1177/107155760000700202 Zobrazit plný text záznamu Full text from SpringerLink