ChemInform Abstract: New Procedure for the Preparation of the Tetrazole Analogue of GABA

Autor:	Yveline Rival, Camille G. Wermuth
Rok vydání:	2010
Předmět:	chemistry.chemical_compound Chemistry Hydrochloride Tetrazole General Medicine Bioisostere Combinatorial chemistry
Zdroj:	ChemInform. 31
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200033130
Popis:	The hydrochloride of the tetrazolyl bioisostere of the neurotransmitter GABA can be easily prepared by means of three simple steps: a Gabriel-type substitution on 4-bromobutyronitrile with Boc2NH, a tetrazole formation by action of azidotributyltin on the cyano group and a deprotection step using gaseous HCl.
Databáze:	OpenAIRE
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