Expression of human papillomavirus in mammary carcinoma and its possible mechanism in carcinogenesis

Autor:	Cheng-yi Hu, Chun-ling Fan, Jing-hua Zhou
Rok vydání:	2008
Předmět:	Mechanism (biology) Immunology Biology medicine.disease_cause medicine.disease Benign breast tumors Mammary carcinoma Breast cancer Virology medicine Cancer research Molecular Medicine Immunohistochemistry Telomerase reverse transcriptase Human papillomavirus Carcinogenesis
Zdroj:	Virologica Sinica. 23:226-231
ISSN:	1995-820X 1674-0769
DOI:	10.1007/s12250-008-2914-2
Popis:	To explore the role of Human papillomavirus (HPV) in mammary carcinogenesis, the expression of the HPV-16, iNOS, P53 and hTERT proteins in breast carcinomas and their relationships were investigated. 52 samples of breast cancer and 16 samples of benign breast tumors were assayed using the immunohistochemical SP method for detection of protein expression levels. The expression of HPV-16, iNOS, P53 and hTERT proteins in a mammary carcinoma was 44.2%, 57.7%, 63.5% and 59.6% respectively, which was significantly greater than the corresponding levels in the benign group. The expression of iNOS, P53 and hTERT was correlated with the presence of an HPV-16 infection in a mammary carcinoma (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::039f36db81f2065c0df9d544678a2b4b https://doi.org/10.1007/s12250-008-2914-2 Zobrazit plný text záznamu Full text from SpringerLink