Study of the metabolism of the new anti-ulcer drug quiditene [(3-quinuclidyl)-di(2-thienyl)carbinol]

Autor:	S. M. Tupikina, Yu. N. Sheinker, L. N. Yakhontov, M. É. Kaminka, O. S. Anisimova, M. V. Polikarpov, E. F. Kuleshova, L. N. Koikov
Rok vydání:	1995
Předmět:	Pharmacology Drug chemistry.chemical_classification Chromatography Ketone Chemistry media_common.quotation_subject Pharmacology toxicology Metabolism Urine Anti ulcer drug Oral administration Drug Discovery Urine sample media_common
Zdroj:	Pharmaceutical Chemistry Journal. 29:26-29
ISSN:	1573-9031 0091-150X
Popis:	Thin-layer chromatography and mass spectrometry were used to study the metabolism of the new anti-ulcer drug Quiditene. After oral administration in a dose of 100 mg/kg, urine samples taken 2 h later showed no metabolites. Later samples (taken 4, 6, 8, and 10 h after administration) revealed three spots belonging to its metabolites in the chromatograms, in addition to the drug itself. Still later samples (taken 24 and 30 h after administration) revealed negligible amounts of the drug and no metabolites. The greatest amounts of metabolites were found in the urine in 6 and 8 h after administration of the drug. The structure of the metabolites was (3-quinuclidyl)-2-thienyl)ketone and its N-oxide. They were synthsized by alternate route to establish their identity and tested for anti-ulcer activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::039dda03fcc719a0781f370e04654046 https://doi.org/10.1007/bf02219457 Zobrazit plný text záznamu Full text from SpringerLink