Learning and memory in the autoimmune BXSB mouse: effects of neocortical ectopias and environmental enrichment
| Autor: | Gary W. Boehm, Victor H. Denenberg, Lynn A. Hyde, Nicholas Waters, Albert M. Galaburda, Gordon F. Sherman, Blair J. Hoplight, Dawn M. Bradway |
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| Rok vydání: | 1996 |
| Předmět: |
medicine.medical_specialty
Environmental enrichment Neocortex General Neuroscience Memoria Central nervous system Cortex (botany) Corticogenesis medicine.anatomical_structure Endocrinology Cerebral cortex Internal medicine medicine Weaning Neurology (clinical) Psychology Molecular Biology Neuroscience Developmental Biology |
| Zdroj: | Brain Research. 726:11-22 |
| ISSN: | 0006-8993 |
| Popis: | Approximately 40–60% of BXSB mice have ectopic cell clusters in layer I of neocortex. Prior studies have shown distinct behavioral differences between those with ectopias and their non-ectopic littermates. In this study, female BXSB mice were reared after weaning in either enriched environments or standard cages. Following an initial round of behavioral testing, all mice were housed in standard cages and retested. Enriched cage mice (both ectopic and non-ectopic) showed increased activity, greater speed, and enhanced learning scores across a variety of tests. Additionally, prior test experience itself had significant positive effects on Hebb-Williams maze learning. The presence of ectopias resulted in better Morris maze learning for standard cage reared mice. Further, ectopic mice, regardless of their housing condition, showed better long-term retention in the Morris maze than did their non-ectopic counterparts. These findings show that abnormalities in corticogenesis need not always result in functional deficit. |
| Databáze: | OpenAIRE |
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