Clinico-hematological profile of multiple myeloma in a teaching hospital - A 2 year study
| Autor: | Naseeruddin Sheik, Sandhya Krupal Variganji, Venkata Renuka Inuganti, Pravallika Uppala, Phani Meghana Bolla |
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| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | IP Archives of Cytology and Histopathology Research. 4:305-309 |
| ISSN: | 2456-9267 2581-5725 |
| Popis: | Introduction: Multiple myeloma accounts for 1% of all cancers and 10-15% of all hematologic malignancies. It is characterized by bone marrow infiltration with clonal plasma cells, production of monoclonal immunoglobulin, and associated end-organ damage. The study aims to find out the incidence of multiple myeloma and to study the clinico-hematological profile along with radiological features. Materials and Methods: The present study was done both retrospectively and prospectively in 26 patients of multiple myeloma diagnosed over a period of 2 years from June 2017 to June 2019 in our teaching hospital. Data from hematological, biochemical, and radiological investigations were collected. For evaluation of each case, revised International Myeloma Working Group criteria were applied. Results: 26 patients were diagnosed during the study period, with the majority of them in the 6th decade with age range was 41-74 years. The male to female ratio was 1.3:1. Most common clinical feature was fever (50%) followed by bone pains (42%) and generalized weakness (42 %). Anemia was the most common hematological manifestation. All the patients had ‘M band’ on serum electrophoresis, and 27% of patients had urinary Bence Jones proteins. Among the skeletal system, the spine (63%) is the most common site of involvement. Conclusion: Among the 26 patients, various clinical presentations observed were pathological fracture, infections, renal impairment, generalized weakness in addition to anemia, and bone pains. Multiple myeloma should be considered as a differential diagnosis in old age patients presenting with such complaints. Keywords: Myeloma, Anemia, M band lytic lesions, Bence Jones protein. |
| Databáze: | OpenAIRE |
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