New phenolic glycosides from Anemone chinensis Bunge and their antioxidant activity
| Autor: | Yu Mu, Wen-Jun Qiao, Xueshi Huang, Yuanyuan Li, Peipei Guan, Jing-Sheng Zhang, Zengguang Zhang, Li Han, Bin Lin |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Antioxidant
DPPH medicine.medical_treatment Plant Science medicine.disease_cause 01 natural sciences Biochemistry Analytical Chemistry chemistry.chemical_compound Western blot medicine chemistry.chemical_classification medicine.diagnostic_test biology 010405 organic chemistry Organic Chemistry Glycoside Glutathione biology.organism_classification 0104 chemical sciences 010404 medicinal & biomolecular chemistry Anemone chinensis Enzyme chemistry Oxidative stress |
| Zdroj: | Natural Product Research. 36:5009-5015 |
| ISSN: | 1478-6427 1478-6419 |
| DOI: | 10.1080/14786419.2021.1917569 |
| Popis: | ABATRACTNine compounds, five phenolic glycosides (1, 2, 4-6), three phenylpropanoids (7-9), and a furanone glycoside (3), were isolated from aqueous soluble extract of the dried roots of Anemone chinensis Bunge. The structures of new compounds (1-4) were elucidated by comprehensive spectroscopic data analysis as well as chemical evidence. Pulsatillanin A (1) demonstrated significant antioxidant effects through scavenging free radical in DPPH assay, and relieved the oxidative stress in LPS-induced RAW 264.7 cells by reducing ROS production, enhancing antioxidant enzyme SOD activity, replenishing depleted GSH in a dose-dependent manner. Western blot analysis revealed that 1 showed antioxidant activity via activating Nrf2 signaling pathway. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|