Stereoselective tetrahydropyrido[2,1-a]isoindolone synthesis via carbanionic and radical intermediates: a model study for the Tacaman alkaloid D/E ring fusion

Autor:	Roger Hunter, Philip Richards
Rok vydání:	2000
Předmět:	Fusion Indole alkaloid Stereochemistry Chemistry Model study Alkaloid Organic Chemistry Drug Discovery Stereoselectivity Biochemistry
Zdroj:	Tetrahedron Letters. 41:3755-3758
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(00)00485-8
Popis:	Stereoselective cyclisation of malic acid-derived α-sulfanyllactam (1) via radical and carbanionic intermediates affords stereo-defined tetrahydropyrido[2,1-a]isoindolones as model compounds for the D/E cis-ring fusion of the Tacaman indole alkaloid skeleton. A transition-state model to explain the stereoselectivity is presented.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0398382d201f613b4c1c52057a74fb3f https://doi.org/10.1016/s0040-4039(00)00485-8 Zobrazit plný text záznamu Full Text from ScienceDirect