Production and Characterization of Monoclonal Antibodies Specific for Prion Protein

Autor:	Hideki Maeno, Takato Matsuo, Mitsuru Naiki, Masanori Morita, Akimasa Ohmizu, Isao Nakata, Shouji Suzuki, Ogata Yoichi
Rok vydání:	2006
Předmět:	business.industry medicine.drug_class animal diseases Disease Monoclonal antibody Virology nervous system diseases Variant cjd Epitope mapping Blood product mental disorders Medicine Prion protein business Screening procedures
Zdroj:	Prions ISBN: 4431255397
DOI:	10.1007/4-431-29402-3_25
Popis:	Creutzfeldt-Jacob disease (CJD) is a neurodegenerative disorder caused by piron, which mainly consists of abnormal prion protein (PrPSc). As PrPSc was detected recently in two patients who received transfusion from preclinical variant CJD (vCJD), concerns about the theoretical risk of transmission of vCJD through blood products increased. In order to contribute the blood products-safety against prion, we aimed at obtaining monoclonal antibodies (mAbs) eligible for screening procedures.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0397fb7cd81ac7a7564d5e3ad7ecb578 https://doi.org/10.1007/4-431-29402-3_25 Zobrazit plný text záznamu