Angustifolinoid A, a macrocyclic flavonoid glycoside from Elaeagnus angustifolia flowers
| Autor: | Guang-Ying Chen, Xiaoyu Chen, Sheng-Ge Li, Hui-Ming Hua, Chi Gong, Yushuang Liu, Tao Yuan |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
chemistry.chemical_classification
Circular dichroism 010405 organic chemistry Chemistry Stereochemistry Organic Chemistry Flavonoid food and beverages Glycoside 010402 general chemistry Ring (chemistry) 01 natural sciences Biochemistry 0104 chemical sciences chemistry.chemical_compound Biosynthesis Intramolecular force Drug Discovery Moiety Oxidative coupling of methane |
| Zdroj: | Tetrahedron Letters. 59:2610-2613 |
| ISSN: | 0040-4039 |
| DOI: | 10.1016/j.tetlet.2018.05.074 |
| Popis: | A novel macrocyclic flavonoid glycoside, angustifolinoid A (1), featuring an unprecedented 13-membered heterocyclic ring moiety, along with a known flavonoid glycoside, tiliroside (2), were isolated from Elaeagnus angustifolia flowers. Their structures were determined by extensive spectroscopic analysis and electronic circular dichroism (ECD) calculation. Biosynthesis analysis indicated that compound 1 might be derived from compound 2 via a key enzymatic intramolecular oxidative coupling. Compounds 1 and 2 showed inhibitory activities against cyclooxygenases, COX-1 and COX-2. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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