A Serum Cytokine Network in Immunoglobulin a Nephropathy
| Autor: | Sang Hoon Woo, Bryan D. Myers, Sanchita Bhattacharya, Isabella Taylor, Richard A. Lafayette, Geraldine C. Derby |
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| Rok vydání: | 2012 |
| Předmět: |
Immunoglobulin A
Pathology medicine.medical_specialty biology business.industry medicine.medical_treatment Matrix (biology) urologic and male genital diseases medicine.disease Nephropathy Pathogenesis Serum cytokine Cytokine Immunology biology.protein Medicine Glomerular disease Immunoglobulin A Nephropathy business |
| Zdroj: | Nephrology Research & Reviews. 4:36-41 |
| ISSN: | 2035-813X |
| Popis: | Individual cytokines have been reported to be associated with the pathogenesis and prognosis of immunoglobulin A (IgA) nephropathy (IgAN). We attempted to characterize a broad cytokine matrix in the serum of patients, and investigate its association with renal function. Thirty-two cytokines were simultaneous-ly measured from the serum of IgAN patients (n=22) and healthy controls (n=12). Clinical variables including annual inulin based GFR and 24-h proteinuria were collected on the IgAN patients over a 5-year period. There was a significant difference between serum cytokine signature of IgAN and control values. There was a significant increase in 9 serum cytokines in IgAN patients compared with healthy controls, and these consisted of inflammatory cytokines, growth factors and chemokines. These 9 cytokines demonstrated significant inter-correlation and formed a distinct pattern compared to controls. IgAN appears to be associated with the elevation of multiple serum cytokines in a highly coordi-nated fashion. The pattern of cytokine changes could serve as a disease biomarker and may provide insights into disease pathogenesis. |
| Databáze: | OpenAIRE |
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