| Autor: |
Robert E. Campbell, Klaus Ballanyi, C. C. H. Laursen, Kaspar Podgorski, Vladimir Rancic, B. R. Taylor, Alan R. Kay, Martin Becker, Hajime Hirase, Matyáš Fendrych, Yi Shen, Nelson B.C. Serre, Yurong Wen, M. J. Lemieux, Sheng-Yi Wu, M. Nedergaard, Daniel F. Eberl, A. G. Dietz, Aneel K. Aggarwal |
| Rok vydání: |
2021 |
| Předmět: |
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| DOI: |
10.1101/2021.10.07.463410 |
| Popis: |
Potassium ions (K+) play a critical role as an essential electrolyte in all biological systems. Here we report the crystal structure-guided optimization and directed evolution of an improved genetically encoded fluorescent K+ biosensor, GINKO2. GINKO2 is highly sensitive and specific for K+ and enables in vivo detection of K+ dynamics in multiple species. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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