Disseminated Intravascular Coagulation During Induction Treatment With Rabbit-Derived Antithymocyte Globulin For Kidney Transplant

Autor:	Christopher Court, Meredith Barrett, Raviprasenna Parasuraman, Douglas A. Colquhoun, Kaylee Clark, Katie McMurry, Dirk J. van der Windt, Abhijit S. Naik, Evan A. Farkash, Kenneth J. Woodside
Rok vydání:	2022
Předmět:	Disseminated intravascular coagulation Transplantation Kidney business.industry medicine.medical_treatment Volume overload medicine.disease Immune complex Hypersensitivity reaction medicine.anatomical_structure Respiratory failure Anesthesia medicine Plasmapheresis Hemodialysis business
Zdroj:	Experimental and Clinical Transplantation. 20:306-310
ISSN:	2146-8427 1304-0855
DOI:	10.6002/ect.2020.0562
Popis:	Rabbit antithymocyte globulin is a lymphocytedepleting agent commonly used as induction therapy in kidney transplants. Although its use is generally safe and well tolerated, serious side effects can occur. Here, we describe a case of a severe immune complex hypersensitivity reaction with disseminated intravascular coagulation in response to rabbit antithymocyte globulin infusion. Immediate treatment required return to the operating room, massive transfusion of blood products, and plasmapheresis. The patient's posttransplant course was significant for volume overload, prolonged respiratory failure, and delayed graft function that required hemodialysis, but within 10 weeks the patient had made a full recovery and kidney allograft function had returned to normal.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0369aa0e530676d73a9b850a35e44f41 https://doi.org/10.6002/ect.2020.0562 Zobrazit plný text záznamu