Correlating Schizophrenia with DRD3 Ser9Gly or HTR2 Receptor Gene Variants by using RFLP Method

Autor:	Mohammed Ayyed Najm, Ali Talib Abid Salih, Zeina S. M. Al –Hadeithi
Rok vydání:	2020
Předmět:	Genetics Health Toxicology and Mutagenesis Biology Toxicology Pathology and Forensic Medicine Exon Dopamine receptor D3 Specific primers Healthy individuals Restriction fragment length polymorphism Gene sequence Receptor Law Gene
Zdroj:	Indian Journal of Forensic Medicine & Toxicology.
ISSN:	0973-9130 0973-9122
DOI:	10.37506/ijfmt.v14i3.10727
Popis:	Genetic polymorphism in many candidates associated with psychiatric disorder and Schizophrenia (SCZ). The current research is directed to see if the polymorphisms of Dopamine Receptor D3 (DRD3) or of the 5-Hydroxytryptamine Type 2A (HTR2A) genes is related to SCZ patients. From those admitted to Al Rasheed Hospital, fifty patients with SCZ (half of them are males and the other half are females), in addition to control group (25 healthy individuals) were included in this study. Blood samples from each individual in both, healthy and control groups were collected, DNA was extracted. Specific primers for exon1 and another for exon 2 have been used to amplify the genes of DRD3 receptor and HTR2A. The data generated in this study indicated significant positive association between T102C polymorphism of HTR2A A1804G transition and DRD3 gene sequence, that resulted in the substitution of Ser9Gly amino acid Iraqi SCZ patients.
Databáze:	OpenAIRE
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