Synthesis, Characterization and Cytotoxicity of Ni (II), Pd (II), Pt (II) Complexes with 6-Methoxy-2, 3, 4, 5-tetrahydropyridine (MTP)

Autor:	Zena Mashal Al-Daly, Hikmat Ali Mohamad, Ali Nafia Najim, Widad Taha Al-Kattan
Rok vydání:	2020
Předmět:	03 medical and health sciences 0302 clinical medicine Chemistry 030220 oncology & carcinogenesis Drug Discovery Environmental Chemistry General Chemistry 010402 general chemistry Cytotoxicity 01 natural sciences Biochemistry Medicinal chemistry 0104 chemical sciences
Zdroj:	Oriental Journal Of Chemistry. 36:903-907
ISSN:	2231-5039 0970-020X
Popis:	Reaction of 2 moles of (MTP) with one mole of MCl2 gave colored complexes with general formula; [M(MTP)2Cl2]. [M = Ni+2, Pd+2, and Pt+2]. All synthesized complexes are well-characterized using, FT-IR, 1HNMR, 13C NMR, UV-Vis. Spectra furthermore of magnetic susceptibility, C,H,N analysis, and molar conductivity. The results illustrated that divalent metal ions were coordinated with the ligands through nitrogen atoms in square planar spatial arrangements. The complexes were screened for their cytotoxicity effects versus MCF-7 cell line and showed that [Pt(MTP)2Cl2] complex has good cytotoxicity in comparison with the other complexes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0365a8beb7b777fc5dba99b90235628e https://doi.org/10.13005/ojc/360515 Zobrazit plný text záznamu