A Method for Performing Full-Thickness, Orthotopic, Penetrating Keratoplasty in the Mouse

Autor:	Si Chun She, Edward J Moticka, Lance P Steahly
Rok vydání:	1990
Předmět:	Pathology medicine.medical_specialty Graft failure Graft rejection business.industry Rat model Congenic Surgery Transplantation medicine.anatomical_structure Cornea medicine Full thickness business Corneal graft failure
Zdroj:	Ophthalmic Surgery, Lasers and Imaging Retina. 21:781-785
ISSN:	2325-8179 2325-8160
DOI:	10.3928/1542-8877-19901101-08
Popis:	In an attempt to overcome the lack of well characterized, inbred, and congenie strains, as well as a paucity of immunological reagents, in rabbit and rat models, we have developed a procedure for performing full-thickness, penetrating keratoplasty in the mouse. One hundred percent of isografts (BALB/c onto BALB/ c) were successful, while 83.3% of allografts (C3H onto BALB/c) failed. The use of a mouse model to study corneal graft failure will allow a critical evaluation of the role of a variety of immunological mediators in causing graft failure.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::035dcb02bcb28721077c2ff4a18305ef https://doi.org/10.3928/1542-8877-19901101-08 Zobrazit plný text záznamu