High-Sensitivity C-Reactive Protein in Patients Undergoing Contrast Studies
| Autor: | Jos eacute, Mariana Santino, Carlos Carraro-Eduardo, Iuna Almeida Deveza, Danielle Calil de Sousa, Diego Cerqueira Alexandre, Luis Guillermo Coca Velarde |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
biology business.industry medicine.medical_treatment C-reactive protein Iodinated Contrast Agent 030204 cardiovascular system & hematology medicine.disease Gastroenterology Iopamidol Surgery Nephropathy 03 medical and health sciences 0302 clinical medicine Iodinated contrast Diabetes mellitus Internal medicine medicine biology.protein 030212 general & internal medicine Prospective cohort study business Cardiac catheterization medicine.drug |
| Zdroj: | International Journal of Cardiovascular Sciences. 29 |
| ISSN: | 2359-4802 |
| DOI: | 10.5935/2359-4802.20160006 |
| Popis: | Background: The use of iodinated agents in radiological studies can cause contrast-induced nephropathy (CIN) in the presence of classic risk factors such as previous renal disease and diabetes. High serum levels of highsensitivity C-reactive protein (CRP) have been described as indicators of increased risk of CIN. Regardless of the occurrence of CIN, hs-CRP may rise after contrast studies. Objective: To investigate the behavior of hs-CRP in patients undergoing parenteral administration of iodinated contrast agent. Methods: Observational cross-sectional prospective study held at Hospital Universitario Antonio Pedro from 2007 to 2014 involving 51 patients, 30 men and 21 women, mean age 60.19±20.0, undergoing tests with lowosmolality contrast (Iopamidol 612 mg/ml). Results: CIN occurred in 15 patients (29.4%). There was no correlation between increased hs-CRP and occurrence of CIN. The percentage increase in hs-CRP was significantly higher among patients undergoing cardiac catheterization (p=0.0044). The mean increase in hs-CRP in patients undergoing cardiac catheterization and in those submitted to administration of iodinated contrast by peripheral vein was 100.3% and 13.8%, respectively. Conclusion: The findings suggest that increased hs-CRP after cardiac catheterization cannot be attributed to iodinated contrast agent. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|