A gamma delta+ T-cell leukemia bearing a novel t(8;14)(q24;q11) translocation demonstrates spontaneous in vitro natural killer-like activity
| Autor: | Lindsay Frazier, Jack L. Strominger, Ramana Tantravahi, Masataka Kasai, Shelly C. Bernstein, Richard T. Maziarz, Robert J. Arceci, Brian R. Smith |
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| Rok vydání: | 1992 |
| Předmět: |
T cell
Immunology T-cell receptor Chromosomal translocation Cell Biology Hematology Biology medicine.disease Major histocompatibility complex Biochemistry Virology Molecular biology Cytolysis Leukemia medicine.anatomical_structure Acute lymphocytic leukemia medicine biology.protein Gamma delta T cell |
| Zdroj: | Blood. 79:1523-1531 |
| ISSN: | 1528-0020 0006-4971 |
| Popis: | A highly malignant human T-cell leukemia was identified by cell surface analysis as a member of the T-cell receptor (TCR) gamma delta lineage. Cytogenetic and molecular analysis showed a novel t(8;14)(q24;q11) rearrangement involving the J delta 1 gene segment on chromosome 14 and the distal end of chromosome 8 near the c-myc proto-oncogene locus. The gamma delta TCR of the leukemia blasts was functionally intact and could be activated to generate intracellular calcium flux and to target Fc receptor-mediated redirected tumor cell lysis. In addition, non- major histocompatibility complex restricted lysis of a limited target cell panel was shown by fresh leukemic blasts and by the in vitro- maintained leukemia cells that was comparable to known T-cell lines with natural killer-like activity. These data suggest that the T-cell leukemia potentially had in vivo functional cytolytic activity. However, whether this activity did contribute to the patient's clinical condition could not be determined. |
| Databáze: | OpenAIRE |
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