Enantioselective synthesis of diisopropyl α-, β-, and γ-hydroxyarylalkylphosphonates from ketophosphonates: A study on the effect of the phosphonyl group

Autor:	Wolfgang H.G. Laux, Chris Meier
Rok vydání:	1996
Předmět:	chemistry.chemical_compound chemistry Stereochemistry Organic Chemistry Drug Discovery Enantioselective synthesis Biochemistry Catecholborane Acetophenone Catalysis
Zdroj:	Tetrahedron. 52:589-598
ISSN:	0040-4020
Popis:	A comparative study of different reduction conditions to an enantioselective synthesis of diisopropyl α-, β- and γ-hydroxyphosphonates 4–6 by 1.3.2-oxazaborolidine catalysis using catecholborane 7 or BH 3 ·Me 2 S 8 is described. The comparison to acetophenone reductions gave information's on the effect of the phosphonyl group during the reduction of ketophosphonate. So very efficient syntheses to chiral dialkyl α-, β- and γ-hydroxyphosphonates were elaborated.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::033a860aeeebba91b39f54020af3b8b9 https://doi.org/10.1016/0040-4020(95)00855-1 Zobrazit plný text záznamu Full Text from ScienceDirect