Diagnostic efficacy of electron microscopy and pleural effusion cytology for the distinction of pleural mesothelioma and lung adenocarcinoma

Autor:	Oscar Arrieta, Carlos González-Carrillo, Alejandra Lara-Garcia, Hugo Dominguez-Malagon, Mariana Lopez-Mejia, Yelitza Esmeralda Campos-Salgado, Ana María Cano-Valdez, José Francisco Corona-Cruz
Rok vydání:	2016
Předmět:	0301 basic medicine Pathology medicine.medical_specialty Lung business.industry Pleural effusion respiratory system medicine.disease respiratory tract diseases Pathology and Forensic Medicine 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Structural Biology 030220 oncology & carcinogenesis Cytology medicine Adenocarcinoma Immunohistochemistry Mesothelioma Pleural Neoplasm Radiology Differential diagnosis business
Zdroj:	Ultrastructural Pathology. 40:254-260
ISSN:	1521-0758 0191-3123
Popis:	The diagnosis of malignant pleural mesothelioma (MPM) is challenging and requires immunohistochemistry or electron microscopy assays to specifically differentiate MPM from lung adenocarcinoma. An ultrastructural study of fresh tissue is considered to be the "gold standard." In most cases, the first diagnostic approach is performed on pleural effusion, and in some patients, this is the only available sample for diagnosis. The aim of the present study is to evaluate if an examination of pleural effusion samples based on electron microscopy (EMpe) is a useful tool for the differential diagnosis of MPM and lung adenocarcinoma. An EMpe study was performed in 25 pleural effusion samples. Histological and immunohistochemical markers confirmed the diagnosis of either mesothelioma (5) or adenocarcinoma (20). Of the five cases that were diagnosed with mesothelioma, two samples (40%) showed cells with "bushy" microvilli, which are characteristic of mesothelioma, by EMpe, and three were acellular (60%). Of the 20 cases of adenocarcinoma, EMpe showed cells with short microvilli in 9 (45%), and 11 were acellular (55%). EMpe identifies unequivocal morphological changes that are useful for the differential diagnosis of MPM or adenocarcinoma when the pleural effusion sample contains evaluable tumor cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0338c6709080714a2fbcace8741fcd6d https://doi.org/10.1080/01913123.2016.1195469 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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