Tobacco Smoke Plays an Important Role in Initiation and Development of Lung Cancer by Promoting the Characteristics of Cancer Stem Cells
| Autor: | Qiaoyan Liang, Zhao Feng Liang, Lei Feng, Ling Lu, Longtao Jin, Shiyue Shen |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
business.industry Mechanism (biology) Molecular pathogenesis Cancer Drug resistance respiratory system medicine.disease Tobacco smoke respiratory tract diseases 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Oncology Cancer stem cell 030220 oncology & carcinogenesis medicine Cancer research Risk factor Lung cancer business |
| Zdroj: | Cancer Management and Research. 12:9735-9739 |
| ISSN: | 1179-1322 |
| DOI: | 10.2147/cmar.s272277 |
| Popis: | Lung cancer is one of the most common causes of cancer-related deaths worldwide. Tobacco smoke is the single greatest risk factor of lung cancer. Although enormous progress in understanding the molecular mechanisms by which tobacco smoke leading to lung cancer has been made, the molecular pathogenesis remains largely unclear. Cancer stem cells have been implicated in cancer initiation, development, and drug resistance. In this review, we reviewed the relationship between tobacco smoke and lung cancer, the key role of cancer stem cells in lung cancer and other tumors. More importantly, we elucidate the mechanism of tobacco smoke promoting lung cancer from the perspective of the characteristics of cancer stem cells induced by tobacco smoke. |
| Databáze: | OpenAIRE |
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