1184-P: Efficacy of Hydroxychloroquine (HCQ) 400mg in Patients with Poorly Controlled Insulin-Treated Type 2 Diabetes Mellitus
| Autor: | Dinesh Agarwal, Rishad Ahmed, A. Natarajan, Amit Bhushan Sharma, A. Shankar Narayanan |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
business.industry Endocrinology Diabetes and Metabolism Insulin medicine.medical_treatment Hydroxychloroquine Type 2 diabetes medicine.disease Gastroenterology Metformin Sitagliptin Internal medicine Internal Medicine medicine In patient Insulin treated type 2 diabetes mellitus business medicine.drug Glycemic |
| Zdroj: | Diabetes. 68 |
| ISSN: | 1939-327X 0012-1797 |
| DOI: | 10.2337/db19-1184-p |
| Popis: | Objective: We retrospectively investigated the effects of adding HCQ 400 mg in patients with type 2 diabetes showing sub-optimal control by basal insulin and other OHA therapy. Method: This is an open label, parallel group, retrospective and multicentre observational study. 123 patients with poorly controlled type 2 diabetes (baseline HbA1c 8.5 ± 0.6%) who are on basal insulin (glargine) with other OHA therapy (metformin 1gm+Sitagliptin 100 mg), were given HCQ 400 mg in addition to insulin. FPG, PPG and HbA1c values, daily insulin dose, body weight and the number of hypoglycemic events were recorded at weeks 0, 12 and 24. Result: HbA1c decreased by 1.6%, from 8.5 ± 0.6% to 6.9 ± 0.8% (P Conclusion: Administration of HCQ 400 mg resulted in sustained improvement in glycemic control when given as an adjunct to insulin therapy in patients with poorly controlled type 2 diabetes. Disclosure R. Ahmed: None. A. Sharma: None. A. Natarajan: None. D. Agarwal: None. A. Narayanan: None. |
| Databáze: | OpenAIRE |
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